This project will describe several mathematical models for the background information and pedagogical ideas that can be molded into exploratory lessons based on actual modeling techniques for epidemics.
Suppose there is a town with population (
) where a rumor spreads by word of mouth. Each inhabitant who has heard the rumor continues to tell it until he meets someone who has already heard it. Then he stops telling it. Now, divide the town's population into three distinct groups:
Assume that every pair of individuals has equal probability of coming into contact with each other. In other words, the three groups are uniformly mixed. The rumor spreads through SI-encounters where I tells S the rumor then S joins I in the infectious group that is spreading the rumor. The number of possible SI-encounters is . The change in S is proportional to . If the infection rate of the rumor is , then the change in group S can be described by the difference equation in the time interval . Individuals become immune to the rumor (stop spreading it) in one of two ways, either when two persons spreading the rumor meet each other (II- encounter) or when a person spreading the rumor meets someone who has stopped telling it (IR-encounter). There are possible IR-encounters and possible pairs of II-encounters. Since II-encounters remove two people from actively spreading the rumor, then the number of removals is proportional to . Remember, however, that group I is also simultaneously increasing its number by SI-encounters. Let us assume the removal rate is equal to the infection rate (). So, in time interval , . This last equation can be simplified algebraically, since using . Consequently, . There is no reason to develop a corresponding difference equation for, since the population of the town is constant .
Store the initial values for P and A, , then set Ustart=99 and Vstart=1. The rumor ends when (approximately 12 iterations). The graphs are displayed in the figure below, and the table of values can be searched for numerical analysis.
1) Why do we stop the model when ?
2) About what percent of the population never hears the rumor?
3) Find the maximum number of infectives, Imax, during the rumor epidemic? On what day did the Imax occur?
4) About how many immune individuals were there when the rumor ended?
5) If we let the model continue to run, what values will approach? Hint: increase number of iterations.
6) The severity () of the rumor epidemic can be calculated by . Find F for the model above, then explain why this definition of severity is reasonable.
7) How can we "fine-tune" the model to improve our data values?
The answer to question #7, admittedly, depends on the computational tools available and the planned use(s) for the model. Yet, we can "fine-tune" the model by decreasing from 1 to, say, 0.5. In general, the model's functions are given by:
Construct the sequence functions on the TI-82 calculator for Model 1 using the same given values, then generate their corresponding graphs and tables when . How many iterations are needed in each case so that ? Answer question #3 again for and. In which result do you have the most confidence? Why?
Since the number of required iterations is not transparent when setting the SEQ WINDOW, the following TI-82 program will allow entry of initial values and output the necessary number of iterations and .
Experiment, using the TI-82 sequence functions and the program RUMORS, by changing the parameter values . Examine the graphs and table values for each incremental change to a single variable. Can you find values for the initial conditions so that a stable condition exists (relatively no change in S or I)? Can you predict if a rumor will spread or not? Can you find initial values that cause the rumor to become endemic?
Whether or not a rumor will spread is a critical concern. A rumor will spread as long as the infectious group (I) is growing by gaining new members. Mathematically, this can be represented as
.
Without loss of generality, let , then
,
which occurs when
.
This value,
,
is called the rumor threshold. Consequently, if
then rumor spreads (I increases), at
then rumor peaks (maximum I), and if
then rumor declines (I decreases). Moreover, if is less than and =1, no epidemic ensues and is a stable point. For example, why is it that when an epidemic goes through a school, there are some who survive as susceptibles? The calculation of the threshold value shows how this can happen. If is near or below the threshold, then few or no susceptibles will become infected because there is not enough contact or the infectives are removed quickly enough. In short, the critical density of susceptibles necessary to maintain a rumor in Model 1 is
.
In the March 4, 1978 issue of the British Medical Journal there was a report with detailed statistics of a flu epidemic in a boys' boarding school with a total of 763 students. If , find the epidemic threshold, the maximum number of infectives, the total number of unaffected boys, and the severity of the epidemic.
Modify program:RUMORS to fit Model 2, and include as an output the measure of severity (F).