Tilghman, a native of Canada, received her Honors B.Sc. in chemistry from Queen's University in Kingston, Ontario, in 1968. After two years
of secondary school teaching in Sierra Leone, West Africa, she obtained her Ph.D. in biochemistry from Temple University in Philadelphia.
During postdoctoral studies at the National Institutes of Health, she made a
number of groundbreaking discoveries while participating in cloning the first mammalian gene, and then continued to make scientific breakthroughs as an independent investigator at the Institute for Cancer Research in
Philadelphia and an adjunct associate professor of human genetics and biochemistry and biophysics at the University of Pennsylvania.
Tilghman came to Princeton in 1986 as the Howard A. Prior Professor of the Life
Sciences. Two years later, she also joined the Howard Hughes Medical Institute as an investigator and began serving as an adjunct professor in the department of biochemistry at the University of Medicine and Dentistry of New
Jersey-Robert Wood Johnson Medical School. In 1998, she took on additional responsibilities as the founding director of Princeton's multi-disciplinary Lewis-Sigler Institute for Integrative Genomics.
A member of the
National Research Council's committee that set the blueprint for the U.S. effort in the Human Genome Project, Tilghman also was one of the founding members of the National Advisory Council of the Human Genome Project Initiative
for the National Institutes of Health.
She is renowned not only for her pioneering research, but for her national leadership on behalf of women in science and for promoting efforts to make the early careers of young
scientists as meaningful and productive as possible. She received national attention for a report on "Trends in the Careers of Life Scientists" that was issued in 1998 by a committee she chaired for the National
Research Council, and she has helped launch the careers of many scholars as a member of the Pew Charitable Trusts Scholars Program in the Biomedical Sciences Selection Committee and the Lucille P. Markey Charitable Trust
Scholar Selection Committee.
From 1993 through 2000, Tilghman chaired Princeton's Council on Science and Technology, which encourages the teaching of science and technology to students outside the sciences, and in 1996
she received Princeton's President's Award for Distinguished Teaching. She initiated the Princeton Postdoctoral Teaching Fellowship, a program across all the science and engineering disciplines that brings postdoctoral students
to Princeton each year to gain experience in both research and teaching.
Tilghman also has participated in teaching and other programs for alumni on campus and across the country on such topics as science and technology
in the liberal arts curriculum, behavioral genetics and the human genome project.
A member of the American Philosophical Society, the National Academy of Sciences, the Institute of Medicine and the Royal Society of
London, she serves as a Trustee of the Jackson Laboratory, a mammalian genetics institute in Bar Harbor, Maine. She has also been a trustee of Rockefeller University in New York, Cold Spring Harbor Laboratory on Long Island, a
member of the Advisory Council to the Director of the National Institutes of Health and a member of the Scientific Advisory Board of the Whitehead Institute for Biomedical Sciences at the Massachusetts Institute of Technology.
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