Doggy DNA:  The Power of PCR

Background

The 5 E’s

Student Activity

Canine Caper
 
Fifi
 
Gus
 
Blanket
    
Blood
 
Electrophesis
    
Gel

PCR

Doggy
Inheritance

Genome
Connection

Bibliography

Group
Projects

DOG, MANS BEST FRIEND

Introduction
The canine genome project and the human genome project have been underway for the past few years.  As scientists reach the end of these projects what information will be available for research and further development.  Will cloning be the only value?  Or will this information be utilized by the medical and pharmaceutical industry in the detection of disease and the treatment of those diseases.  Do humans and dogs share some common genes? In fact 99% of human genes are also found in dogs.

Connecting Activity
The following activity will send you to the reference area of your library or to a computer with Internet access.  A search for some correlation between the two research projects will be underway.  There are numerous sites on the Internet that report information found on the various chromosomes and there is a direct link between humans and dogs.  Can you find the genes or the loc (location) for the following diseases?

Gene

Canine loc

Human loc

Breast Cancer early onset

CFA9

17q21

Factor VIII (blood clotting)

X

Xq28

Von Willebrand factor

CFA16

12p13.3

Olfactory receptor

CFA9

17q21

Pancreatic lipase

Synt. 14

10q26.1

Summary:
Dogs have been selectively bred for many generations where as the human has not.  What are the positive and negative implications of random and selective breeding? 

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