1993 Woodrow Wilson Biology Institute
Highlights Of Lecture By Arnold Levine, Princeton University MOLECULAR BIOLOGY OF CANCER
Cancer is defined as the loss of cell division control. This is a "Darwinian Problem" of competition in which the cancer cells will take over the normal function. It has been determined that it takes 5-6 mutations in one cell to cause cancer to occur.
This growth curve is an exponential curve, the exponent being 5.5 independent events to cause cancer. In the case of children fewer mutations are necessary.
Growth curve of Cancer
Those who develop cancer from 30-40 years of age probably inherited a pre-disposition to cancer that allows the cells to develop cancerous conditions with fewer mutations.
By 1985 the two types of cancer were determined:
Examples of Oncogenes that have been found work in tissues.
sis Simian Sarcoma PDGF stimulation ras Rat Sarcoma effects G protein erb-B Chicken affects growth receptor sites erthroblastosis src Rous sarcoma Protein kinases cause signals in the S phase myc Myoblastic affects while blood cells leukemiaExamples of Tumor suppressor genes; those that cause negative regulation.
SKIN - any of these cell types can cause cancer.